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A single centre, open-label, cross-over study of pharmacokinetics comparing topical zinc/clindamycin gel (Zindaclin) and topical clindamycin lotion (Dalacin T) in subjects with mild to moderate acne.
- Source :
-
The Journal of dermatological treatment [J Dermatolog Treat] 2006; Vol. 17 (3), pp. 154-7. - Publication Year :
- 2006
-
Abstract
- Zinc/clindamycin gel (Zindaclin 1%) gel, is a new once-daily topical acne treatment (Strakan Ltd) containing clindamycin phosphate equivalent to 1% clindamycin and zinc acetate in a formulation, which leads to a reduced systemic absorption of clindamycin through the skin. The objective of the study was to compare the systemic absorption of clindamycin from zinc/clindamycin gel and clindamycin lotion (Dalacin T topical lotion, Pharmacia Ltd) after repeated twice-daily topical administration for two periods of 5 days with an intervening gap of 2 weeks in 24 subjects with mild to moderate acne. Plasma Cmax, and AUC0-12 of clindamycin measured after single and multiple applications of zinc/clindamycin gel were between 30% and 50% lower than for clindamycin lotion. As zinc/clindamycin gel is a topical treatment for acne, the lower systemic bioavailability may be beneficial because there may be a correspondingly lower risk of systemic events in zinc/clindamycin gel-treated subjects.
- Subjects :
- Acne Vulgaris blood
Acne Vulgaris pathology
Administration, Cutaneous
Adolescent
Adult
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Area Under Curve
Clindamycin administration & dosage
Cross-Over Studies
Drug Combinations
Female
Humans
Male
Severity of Illness Index
Skin Absorption
Treatment Outcome
Zinc Acetate administration & dosage
Zinc Acetate therapeutic use
Acne Vulgaris drug therapy
Anti-Bacterial Agents pharmacokinetics
Clindamycin pharmacokinetics
Clindamycin therapeutic use
Zinc Acetate pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0954-6634
- Volume :
- 17
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of dermatological treatment
- Publication Type :
- Academic Journal
- Accession number :
- 16854755
- Full Text :
- https://doi.org/10.1080/09546630600727115