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Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs.
- Source :
-
Nature immunology [Nat Immunol] 2006 Aug; Vol. 7 (8), pp. 827-34. Date of Electronic Publication: 2006 Jul 16. - Publication Year :
- 2006
-
Abstract
- The migration of B cells into secondary lymphoid organs is required for the generation of an effective immune response. Here we analyzed the involvement of SWAP-70, a Rac-interacting protein involved in actin rearrangement, in B cell entry into lymph nodes. We noted reduced migration of Swap70-/- B cells into lymph nodes in vivo. Swap70-/- B cells rolled and adhered, yet accumulated in lymph node high endothelial venules. This defect was not due to impaired integrin expression or chemotaxis. Instead, Swap70-/- B cells aberrantly regulated integrin-mediated adhesion. During attachment, Swap70-/- B cells showed defective polarization and did not form uropods or stabilize lamellipodia at a defined region. Thus, SWAP-70 selectively regulates processes essential for B cell entry into lymph nodes.
- Subjects :
- Animals
B-Lymphocytes cytology
Cell Movement immunology
Lymph Nodes cytology
Lymphocyte Activation immunology
Mice
Minor Histocompatibility Antigens
B-Lymphocytes immunology
DNA-Binding Proteins immunology
Guanine Nucleotide Exchange Factors immunology
Lymph Nodes immunology
Nuclear Proteins immunology
Receptors, Lymphocyte Homing immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1529-2908
- Volume :
- 7
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nature immunology
- Publication Type :
- Academic Journal
- Accession number :
- 16845395
- Full Text :
- https://doi.org/10.1038/ni1365