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Decrease in triglyceride level by bezafibrate is related to reduction of recurrent coronary events: a Bezafibrate Infarction Prevention substudy.
- Source :
-
Coronary artery disease [Coron Artery Dis] 2006 Aug; Vol. 17 (5), pp. 455-61. - Publication Year :
- 2006
-
Abstract
- Background: Fibrates were reported to be effective in reducing recurrent coronary events in coronary heart disease patients with elevated triglycerides. It is not known whether this effect is related to the extent of triglyceride reduction.<br />Methods: Participants comprised 3090 coronary heart disease patients enrolled in the Bezafibrate Infarction Prevention study, which showed a nonsignificant reduction (9.4%; P=0.26) in fatal or nonfatal myocardial infarction and sudden death during a mean follow-up time of 6.2 years.<br />Results: Significant reduction in triglyceride serum level was evident only among patients allocated to bezafibrate, ranging between 0.06 mmol/l (5 mg/dl) in the lowest decile of baseline triglycerides level and 0.68 mmol/l (60 mg/dl) in the highest baseline decile. The extent of triglyceride reduction with bezafibrate was significantly associated with the reduction of risk; relative risk reduction of 55% (hazards ratio: 0.45; 95% confidence interval: 0.24-0.84) was observed among patients with baseline triglycerides>or=2.26 mmol/l who reduced triglyceride level to >0.50 mmol/l (>44.3 mg/dl). In contrast, the risk of recurrent events among patients treated with bezafibrate and achieving less triglyceride reduction or failing to reduce triglyceride level was not significantly different from that of patients treated with placebo.<br />Conclusion: Bezafibrate treatment was associated with significant risk reduction among coronary heart disease patients with elevated triglyceride levels that substantially reduced their triglyceride level with treatment.
- Subjects :
- Aged
Bezafibrate therapeutic use
Clofibric Acid therapeutic use
Female
Humans
Hypolipidemic Agents therapeutic use
Male
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
Bezafibrate pharmacology
Clofibric Acid pharmacology
Hypertriglyceridemia drug therapy
Hypolipidemic Agents pharmacology
Secondary Prevention
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 0954-6928
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Coronary artery disease
- Publication Type :
- Academic Journal
- Accession number :
- 16845254
- Full Text :
- https://doi.org/10.1097/01.mca.0000224406.60573.8e