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GYKI-12743 a new postsynaptic vascular alpha-adrenoceptor antagonist.
- Source :
-
Acta physiologica Hungarica [Acta Physiol Hung] 1991; Vol. 77 (3-4), pp. 257-67. - Publication Year :
- 1991
-
Abstract
- Using the pithed rat preparation it has been proven that GYKI-12743 exerted its alpha-adrenergic blocking action only at the postsynaptic vascular level in the cardiovascular system. This new molecule failed to antagonize the presynaptic alpha 2-adrenoceptors of the cardiac sympathetic nerve endings. Thereby it was possible to demonstrate the first vasoselective postsynaptic adrenoceptor antagonist which potentially might be interesting in the cardiovascular therapy.
- Subjects :
- Animals
Azepines pharmacology
Clonidine pharmacology
Decerebrate State
Electric Stimulation
Idazoxan
Phentolamine pharmacology
Phenylephrine pharmacology
Rats
Rats, Inbred Strains
Yohimbine pharmacology
Adrenergic alpha-Antagonists pharmacology
Blood Pressure drug effects
Dioxanes pharmacology
Heart Rate drug effects
Pyridazines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0231-424X
- Volume :
- 77
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Acta physiologica Hungarica
- Publication Type :
- Academic Journal
- Accession number :
- 1684485