A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.

Authors :: Lu BZ
Zhao W
Wei HX
Dufour M
Farina V
Senanayake CH
Source :: Organic letters [Org Lett] 2006 Jul 20; Vol. 8 (15), pp. 3271-4.
Publication Year :: 2006
Abstract: [Structure: see text] A practical one-pot, regiospecific three-component process for the synthesis of 2,3-disubstituted indoles was developed via consecutive Pd-catalyzed Sonogashira coupling, amidopalladation, and reductive elimination.

Subjects :: Catalysis
Molecular Structure
Palladium chemistry
Combinatorial Chemistry Techniques
Indoles chemical synthesis

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