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In vivo measurement of retinal physiology with high-speed ultrahigh-resolution optical coherence tomography.
- Source :
-
Optics letters [Opt Lett] 2006 Aug 01; Vol. 31 (15), pp. 2308-10. - Publication Year :
- 2006
-
Abstract
- Noninvasive in vivo functional optical imaging of the intact retina is demonstrated by using high-speed, ultrahigh-resolution optical coherence tomography (OCT). Imaging was performed with 2.8 microm resolution at a rate of 24,000 axial scans per second. A white-light stimulus was applied to the dark-adapted rat retina, and the average reflectivities from different intraretinal layers were monitored as a function of time. A 10%-15% increase in the average amplitude reflectance of the photoreceptor outer segments was observed in response to the stimulus. The spatial distribution of the change in the OCT signal is consistent with an increase in backscatter from the photoreceptor outer segments. To our knowledge, this is the first in vivo demonstration of OCT functional imaging in the intact retina.
- Subjects :
- Animals
Computer Systems
Image Enhancement instrumentation
Image Interpretation, Computer-Assisted instrumentation
Ophthalmoscopes
Photic Stimulation methods
Photoreceptor Cells radiation effects
Rats
Rats, Long-Evans
Tomography, Optical Coherence instrumentation
Image Enhancement methods
Image Interpretation, Computer-Assisted methods
Ophthalmoscopy methods
Photoreceptor Cells cytology
Photoreceptor Cells physiology
Tomography, Optical Coherence methods
Subjects
Details
- Language :
- English
- ISSN :
- 0146-9592
- Volume :
- 31
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Optics letters
- Publication Type :
- Academic Journal
- Accession number :
- 16832468
- Full Text :
- https://doi.org/10.1364/ol.31.002308