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Antibiotic stress induces genetic transformability in the human pathogen Streptococcus pneumoniae.
- Source :
-
Science (New York, N.Y.) [Science] 2006 Jul 07; Vol. 313 (5783), pp. 89-92. - Publication Year :
- 2006
-
Abstract
- Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to antibiotic stress, S. pneumoniae, which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics.
- Subjects :
- Aminoglycosides pharmacology
Bacterial Proteins metabolism
Enzyme Inhibitors pharmacology
Fluoroquinolones pharmacology
Gene Expression Regulation, Bacterial
Protein Synthesis Inhibitors pharmacology
Rec A Recombinases biosynthesis
Rec A Recombinases genetics
Recombinant Fusion Proteins metabolism
Regulon drug effects
SOS Response, Genetics
Streptococcus pneumoniae metabolism
Anti-Bacterial Agents pharmacology
Mitomycin pharmacology
Streptococcus pneumoniae drug effects
Streptococcus pneumoniae genetics
Transformation, Bacterial
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 313
- Issue :
- 5783
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 16825569
- Full Text :
- https://doi.org/10.1126/science.1127912