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[Study of urothelial bladder tumours in renal transplant recipients].
- Source :
-
Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie [Prog Urol] 2006 Jun; Vol. 16 (3), pp. 343-6. - Publication Year :
- 2006
-
Abstract
- Objective: To study the prevalence, treatment and outcome of urothelial bladder tumours (UBT) in renal transplant recipients.<br />Patients and Methods: Multicentre retrospective study performed in 2004 by questionnaire sent to members of the AFU Transplantation Committee.<br />Result: Seven centres returned the questionnaire with a total of 32 UBTs in 21 males and 3 females with a mean age of 63.2 +/- 10.1 years, with no history of UBT. The incidence was 255 per 100,000. The median interval between transplantation and UBT was 60 months (range: 5 to 259 months). 72% of UBTs were stage pT > or = 1 and 63% were grade 3. CIS was present in 20% of cases. 25% of patients were N+. In addition to resection of the UBT, 3 patients were also treated with mitomycin C and 1 was treated with BCG. 7 patients underwent cystectomy, with a palliative objective in 42% of cases, associated with radiotherapy-chemotherapy (2/3) or chemotherapy alone (1/3). Immunosuppressive therapy was decreased in 50% of cases. Six patients (25%) died from bladder cancer, 25% relapsed with a tumour progression rate of 50%. 46% of patients were in remission of their UBT 4% died from an intercurrent cause. 76% of survivors have a Junctional graft with no alteration of serum creatinine.<br />Conclusion: Renal transplant recipients have an increased incidence of UBT, which are more aggressive and associated with a higher mortality compared to the general population. Increased surveillance and aggressive treatment therefore appear to be justified.
Details
- Language :
- French
- ISSN :
- 1166-7087
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie
- Publication Type :
- Academic Journal
- Accession number :
- 16821348