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Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands.

Authors :
Wildonger KJ
Ratcliffe RW
Mosley RT
Hammond ML
Birzin ET
Rohrer SP
Source :
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Sep 01; Vol. 16 (17), pp. 4462-6. Date of Electronic Publication: 2006 Jul 11.
Publication Year :
2006

Abstract

A series of 2-9a bridged tetrahydrofluorenone derivatives were prepared which exhibited significant binding affinity for ERbeta and were highly selective.

Details

Language :
English
ISSN :
0960-894X
Volume :
16
Issue :
17
Database :
MEDLINE
Journal :
Bioorganic & medicinal chemistry letters
Publication Type :
Academic Journal
Accession number :
16815012
Full Text :
https://doi.org/10.1016/j.bmcl.2006.06.043