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Stereoselective synthesis of some 17beta-dihydrooxazinyl steroids, as novel presumed inhibitors of 17alpha-hydroxylase-C17,20-lyase.
- Source :
-
Steroids [Steroids] 2006 Sep; Vol. 71 (9), pp. 809-16. Date of Electronic Publication: 2006 Jun 30. - Publication Year :
- 2006
-
Abstract
- 17beta-Dihydrooxazinyl steroids 5a-l and 6a-l were synthetized. The acid-catalyzed reactions of 21-azidomethyl-20-hydroxy- and 21-hydroxymethyl-20-azidosteroids with substituted aromatic aldehydes led to the formation of androst-5-en-3beta-ols substituted in position 17beta with dihydrooxazine residues. The inhibitory effects of these compounds on rat testicular C(17,20)-lyase were investigated with an in vitro radioincubation technique.
Details
- Language :
- English
- ISSN :
- 0039-128X
- Volume :
- 71
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 16814336
- Full Text :
- https://doi.org/10.1016/j.steroids.2006.05.011