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Brain plasticity in recovery from stroke: an MEG assessment.
- Source :
-
NeuroImage [Neuroimage] 2006 Sep; Vol. 32 (3), pp. 1326-34. Date of Electronic Publication: 2006 Jun 27. - Publication Year :
- 2006
-
Abstract
- The aim of this paper was to deepen understanding about the role played by brain plasticity in obtaining clinical recovery. Eighteen patients, who had recovered partially or totally from dysfunctions due to a monohemispheric infarction within the middle cerebral artery territory, underwent magnetoencephalographic (MEG) recordings of rolandic areas cerebral activity both in rest state (spectral power properties) and in response to the electrical stimulation of the contralateral median nerve (M20 and M30 cortical sources). MEG evaluation was performed in acute (T0: mean 5 days from ischemic attach) and post-acute phase (T1: median 6 months). At T1, all the inter-hemispheric asymmetries were reduced for both spontaneous and evoked activity parameters with respect to T0. In post-acute phase, lower cortical excitability, higher delta and theta power and lower spectral entropy were associated to a worse clinical state. An unusual recruitment-as revealed by an excessive inter-hemispheric asymmetry of M20 cortical source position-correlated with higher level of clinical amelioration in the patients who showed a partial recovery. In addition to confirmative evidence that "normalization" of neural activity in both the affected and unaffected hemispheres subtends best clinical recovery, present data provide support to the positive role of cerebral plasticity phenomena--i.e. unusual neural recruitments--to regain lost functions in those patients unable to achieve total recovery.
- Subjects :
- Adult
Aged
Aged, 80 and over
Algorithms
Artifacts
Brain pathology
Cohort Studies
Electric Stimulation
Electroencephalography
Entropy
Female
Functional Laterality physiology
Humans
Magnetic Resonance Imaging
Magnetoencephalography
Male
Median Nerve physiology
Middle Aged
Somatosensory Cortex pathology
Somatosensory Cortex physiopathology
Stroke pathology
Brain physiopathology
Neuronal Plasticity physiology
Stroke physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1053-8119
- Volume :
- 32
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- NeuroImage
- Publication Type :
- Academic Journal
- Accession number :
- 16806985
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2006.05.004