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Managing the pediatric patient and the adolescent/adult transition.

Authors :
Valentino LA
Santagostino E
Blanchette V
van den Berg M
Source :
Seminars in thrombosis and hemostasis [Semin Thromb Hemost] 2006 Jun; Vol. 32 Suppl 2, pp. 28-31.
Publication Year :
2006

Abstract

Healthcare management of the developing child with hemophilia presents several difficulties. Determining the optimum medication dose is complicated by the difficulty of performing pharmacokinetic studies in children and the fact that extrapolation from data collected in adults is generally unsatisfactory. Even when pediatric pharmacokinetic data are available, accumulating evidence suggests that there can be wide interindividual differences; age and size are important contributing factors. Achieving the venous access necessary for blood factor administration is frequently difficult in the small child. Preliminary results suggest that an arteriovenous fistula may be an appropriate option in some patients. Finally, there is the question of whether prophylactic therapy should be discontinued as patients enter adulthood. This article provides insights for managing this challenging patient population.

Details

Language :
English
ISSN :
0094-6176
Volume :
32 Suppl 2
Database :
MEDLINE
Journal :
Seminars in thrombosis and hemostasis
Publication Type :
Academic Journal
Accession number :
16804833
Full Text :
https://doi.org/10.1055/s-2006-946912