Back to Search
Start Over
Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2006 Jul 05; Vol. 103 (27), pp. 10364-10368. Date of Electronic Publication: 2006 Jun 27. - Publication Year :
- 2006
-
Abstract
- The sst1 locus has been identified in a mouse model to control resistance and susceptibility of Mycobacterium tuberculosis infection. Subsequent studies have now identified Ipr1 (intracellular pathogen resistance 1) to be the gene responsible. Ipr1 is encoded within the sst1 locus and is expressed in the tuberculosis lung lesions and macrophages of sst1-resistant, but not sst1-susceptible mice. We have therefore examined the closest human homologue of Ipr1, SP110, for its ability to control susceptibility to M. tuberculosis infection in humans. In a study of families from The Gambia we have identified three polymorphisms that are associated with disease. On examination of additional families from Guinea-Bissau and the Republic of Guinea, two of these associations were independently replicated. These variants are in strong linkage disequilibrium with each other and lie within a 31-kb block of low haplotypic diversity, suggesting that a polymorphism within this region has a role in genetic susceptibility to tuberculosis in humans.
- Subjects :
- Africa epidemiology
Disease Transmission, Infectious
Haplotypes
Humans
Minor Histocompatibility Antigens
Tuberculosis epidemiology
Tuberculosis microbiology
Tuberculosis pathology
Genetic Predisposition to Disease genetics
Genetic Variation genetics
Mycobacterium tuberculosis physiology
Nuclear Proteins genetics
Tuberculosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0027-8424
- Volume :
- 103
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 16803959
- Full Text :
- https://doi.org/10.1073/pnas.0603340103