Back to Search
Start Over
A randomized controlled trial of calcium supplementation to increase bone mineral density in children with juvenile rheumatoid arthritis.
- Source :
-
Arthritis and rheumatism [Arthritis Rheum] 2006 Jul; Vol. 54 (7), pp. 2235-42. - Publication Year :
- 2006
-
Abstract
- Objective: To examine the effects of daily supplementation with calcium (Ca) in combination with vitamin D on total body and lumbar spine bone mineral density (BMD) in patients with juvenile rheumatoid arthritis (JRA) who had not taken corticosteroids for at least 3 months prior to the beginning of the study.<br />Methods: One hundred ninety-eight children and adolescents (141 girls and 57 boys) with JRA, ages 6 to 18 years, with a mean +/- SD age of 11.7 +/- 3.3 years and a mean +/- SD disease duration of 5.6 +/- 3.8 years at the beginning of the study, were enrolled in this randomized double-blind, placebo-controlled trial to receive either daily oral supplements of 1,000 mg of Ca and 400 IU of vitamin D (n = 103) or matched placebo tablets and 400 IU of vitamin D (n = 95) for 24 months. Total body BMD (TBBMD) was measured by dual x-ray absorptiometry at baseline and every 6 months for 24 months.<br />Results: At baseline, the mean +/- SD TBBMD was 0.89 +/- 0.14 gm/cm2 among patients randomized to the Ca group and 0.87 +/- 0.14 gm/cm2 among those randomized to placebo (P = 0.445). At 24 months, the mean +/- SD TBBMD among those receiving Ca was 0.95 +/- 0.13 gm/cm2, compared with 0.92 +/- 0.14 gm/cm2 among those receiving placebo. A longitudinal random-effects mixed model analysis that controlled for differences in the subject's initial BMD, sex, Tanner stage, adherence to the study medication regimen, and body composition revealed significantly higher TBBMD among patients who received Ca compared with patients who received placebo during the study period (P = 0.03).<br />Conclusion: Ca supplementation resulted in a small, but statistically significant, increase in TBBMD compared with placebo in children with JRA.
- Subjects :
- Adolescent
Arthritis, Juvenile drug therapy
Body Composition drug effects
Bone Density drug effects
Bone Resorption etiology
Bone and Bones drug effects
Bone and Bones pathology
Calcium pharmacology
Child
Dietary Supplements
Double-Blind Method
Female
Humans
Male
Prospective Studies
Vitamin D pharmacology
Vitamin D therapeutic use
Arthritis, Juvenile complications
Arthritis, Juvenile physiopathology
Bone Density physiology
Bone Resorption drug therapy
Calcium therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0004-3591
- Volume :
- 54
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Arthritis and rheumatism
- Publication Type :
- Academic Journal
- Accession number :
- 16802360
- Full Text :
- https://doi.org/10.1002/art.21956