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Long-term habituation of the smile response with deep brain stimulation.
- Source :
-
Neurocase [Neurocase] 2006 Jun; Vol. 12 (3), pp. 191-6. - Publication Year :
- 2006
-
Abstract
- Human and animal research has shown that the ventral striatum, including the nucleus accumbens, may play a critical role in mediating positive emotions. Recently we described a subject with obsessive-compulsive disorder who intra-operatively exhibited the acute onset of an asymmetric smile and acute positive emotional change with contralateral deep brain stimulation (DBS) in either the right or left nucleus accumbens and anterior limb of the internal capsule region. The purpose of the present study was to examine the stability of the stimulation-induced smile(s) over a 12-month period. Custom computer software objectively quantified left and right facial movement during DBS. Although stimulation-induced smiles were elicited at one and two months post-surgery, they were no longer present from 3-12 months following chronic high frequency DBS. The smiles could not be elicited even with long washout periods. These findings imply potential long-term habituation and changes in the neural chemistry (possibly neuroplasticity) induced by chronic DBS.
- Subjects :
- Adult
Emotions physiology
Emotions radiation effects
Entropy
Evaluation Studies as Topic
Female
Humans
Movement physiology
Movement radiation effects
Time Factors
Deep Brain Stimulation methods
Depressive Disorder, Major physiopathology
Depressive Disorder, Major surgery
Habituation, Psychophysiologic
Subjects
Details
- Language :
- English
- ISSN :
- 1355-4794
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurocase
- Publication Type :
- Academic Journal
- Accession number :
- 16801154
- Full Text :
- https://doi.org/10.1080/13554790600646995