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Effects of theta burst stimulation protocols on phosphene threshold.

Authors :
Franca M
Koch G
Mochizuki H
Huang YZ
Rothwell JC
Source :
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2006 Aug; Vol. 117 (8), pp. 1808-13. Date of Electronic Publication: 2006 Jun 21.
Publication Year :
2006

Abstract

Objective: We investigated the effects on occipital cortex, of two newly developed methods of repetitive transcranial magnetic stimulation (rTMS): continuous and intermittent theta burst stimulation (cTBS and iTBS), that lead to long lasting changes in excitability when applied over primary motor cortex.<br />Methods: Phosphene threshold to a single TMS pulse was measured before and after application of either continuous or intermittent theta burst stimulation (cTBS/iTBS; 600 total pulses at 80% phosphene threshold).<br />Results: In our cohort, cTBS increased phosphene threshold by an average of 10%. In contrast, iTBS, which transiently increases motor cortex excitability, had no effect on phosphene threshold.<br />Conclusions: cTBS can be applied successfully to non-motor areas of cortex, but iTBS may need modification to produce maximal effects.<br />Significance: cTBS maybe a new useful tool in disorders characterized by an abnormal state of activity of the visual cortex.

Details

Language :
English
ISSN :
1388-2457
Volume :
117
Issue :
8
Database :
MEDLINE
Journal :
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Publication Type :
Academic Journal
Accession number :
16797230
Full Text :
https://doi.org/10.1016/j.clinph.2006.03.019