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BCL10 gene amplification associated with strong nuclear BCL10 expression in a diffuse large B cell lymphoma with IGH-BCL2 fusion.
- Source :
-
Haematologica [Haematologica] 2006 Jun; Vol. 91 (6 Suppl), pp. ECR28. - Publication Year :
- 2006
-
Abstract
- Cytogenetic investigation of a nodal diffuse large B cell lymphoma carrying an IGH-BCL2-fusion revealed a homogeneously staining region at chromosome 1p21-22. Fluorescence in situ hybridisation (FISH) demonstrated heterogeneous BCL10 gene amplification in tumour cells. Immunohistochemistry showed heterogeneous over-expression of the protein in the nuclei of tumour cells, similar to that seen in MALT lymphoma cells with t(1;14)(p22;q32).
- Subjects :
- B-Cell CLL-Lymphoma 10 Protein
Caspases genetics
Chromosome Mapping
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 14
Forkhead Transcription Factors genetics
Gene Amplification
Gene Expression Regulation, Neoplastic
Humans
Lymphoma, B-Cell pathology
Lymphoma, Large B-Cell, Diffuse pathology
Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein
Neoplasm Proteins genetics
Recombinant Fusion Proteins genetics
Repressor Proteins genetics
Translocation, Genetic
Adaptor Proteins, Signal Transducing genetics
Immunoglobulin Heavy Chains genetics
Lymphoma, B-Cell genetics
Lymphoma, Large B-Cell, Diffuse genetics
bcl-2-Associated X Protein genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 91
- Issue :
- 6 Suppl
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 16785131