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Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand.
- Source :
-
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2006 Aug; Vol. 48 (2), pp. 195-203. Date of Electronic Publication: 2006 May 22. - Publication Year :
- 2006
-
Abstract
- A cis-isomer of a C(8)-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C(8)-diol-ester identified in Dinophysis. The more abundant trans-C(8)-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.
- Subjects :
- Animals
Chromatography, High Pressure Liquid
Esterification
Furans pharmacology
Hepatopancreas metabolism
Hydrolysis drug effects
Macrolides
Magnetic Resonance Spectroscopy
Marine Toxins chemistry
Molecular Structure
Okadaic Acid analogs & derivatives
Okadaic Acid analysis
Pyrans pharmacology
Spectrometry, Mass, Electrospray Ionization
Dinoflagellida chemistry
Marine Toxins isolation & purification
Okadaic Acid isolation & purification
Pyrans chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0041-0101
- Volume :
- 48
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicon : official journal of the International Society on Toxinology
- Publication Type :
- Academic Journal
- Accession number :
- 16784765
- Full Text :
- https://doi.org/10.1016/j.toxicon.2006.04.018