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Association of obesity with treatment outcomes in ovulatory infertile women undergoing superovulation and intrauterine insemination.

Authors :
Dodson WC
Kunselman AR
Legro RS
Source :
Fertility and sterility [Fertil Steril] 2006 Sep; Vol. 86 (3), pp. 642-6. Date of Electronic Publication: 2006 Jun 16.
Publication Year :
2006

Abstract

Objective: To evaluate the association between obesity and the outcome of superovulation and intrauterine insemination (IUI) in infertile ovulatory women.<br />Design: Retrospective chart review.<br />Setting: University-based infertility clinic.<br />Patient(s): Three hundred thirty-three ovulatory women, grouped by body mass index (BMI) categories, who received superovulation and IUI for treatment of infertility.<br />Intervention(s): None.<br />Primary Outcome: cycle fecundity.<br />Secondary Outcomes: total dose of gonadotropins, serum level of E(2), and number of follicles >or=17 mm on the day of hCG injection.<br />Result(s): Adjusted cycle fecundity was not different among BMI groups (underweight: 0.14 [95% CI: {0.07, 0.29}], normal weight: 0.12 [95% CI: {0.09, 0.16}], overweight: 0.17 [95% CI: {0.12, 0.24}], and obese: 0.14 [95% CI: {0.08, 0.23}]). Adjusted total gonadotropin dose (IU/cycle) was greater in obese women than in underweight or normal-weight women. Although the numbers of large follicles were not different, E(2) levels (pg/mL) were lower in obese women than in normal-weight and overweight women.<br />Conclusion(s): Our sample of ovulatory infertile women demonstrated that treatment-related cycle fecundity is unaffected by obesity. We conclude that obese, infertile ovulatory women require a greater dose of gonadotropins to achieve similar levels of superovulation than normal, underweight or overweight women.

Details

Language :
English
ISSN :
1556-5653
Volume :
86
Issue :
3
Database :
MEDLINE
Journal :
Fertility and sterility
Publication Type :
Academic Journal
Accession number :
16782095
Full Text :
https://doi.org/10.1016/j.fertnstert.2006.01.040