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Elevated level of soluble interleukin-2 receptor in bronchoalveolar lavage fluid from sarcoidosis patients.
- Source :
-
Japanese journal of medicine [Jpn J Med] 1991 Mar-Apr; Vol. 30 (2), pp. 113-7. - Publication Year :
- 1991
-
Abstract
- Pulmonary sarcoidosis is a granulomatous disorder of unknown cause, characterized by an accumulation of active T lymphocytes in the lung. We measured the levels of soluble interleukin-2 receptor (IL-2R) in bronchoalveolar lavage fluid (BALF) of patients with active pulmonary sarcoidosis and normal subjects by a sensitive enzyme-linked immunosorbent assay. Soluble IL-2R was detectable in BALF from 6 of 11 patients with sarcoidosis but in only 1 of 8 normal control subjects, the mean levels of IL-2R in BALF of the two groups being 2.8 +/- 0.9 U/ml and 0.1 +/- 0.1 U/ml, respectively (p less than 0.01). A slight correlation was found between the soluble IL-2R level and the number of CD4-positive cells. Sarcoidosis patients were classified by radiographical staging. Soluble IL-2R was not detectable in the BALF of any stage I patients, but was found in the BALF of 6 of the 7 stage II and stage III patients. These results suggest that in the clinical management of patients with sarcoidosis, measurement of soluble IL-2R in BALF is useful for evaluating the activity of the lung disease is sarcoidosis.
- Subjects :
- Adult
Bronchoalveolar Lavage Fluid pathology
CD4-Positive T-Lymphocytes
Enzyme-Linked Immunosorbent Assay
Female
Humans
Leukocyte Count
Lung Diseases pathology
Male
Middle Aged
Sarcoidosis pathology
Smoking
Bronchoalveolar Lavage Fluid chemistry
Lung Diseases metabolism
Receptors, Interleukin-2 analysis
Sarcoidosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5120
- Volume :
- 30
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Japanese journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 1678021
- Full Text :
- https://doi.org/10.2169/internalmedicine1962.30.113