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Management of fluoride induced testicular disorders by calcium and vitamin-E co-administration in the albino rat.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2006 Nov; Vol. 22 (4), pp. 606-12. - Publication Year :
- 2006
-
Abstract
- Fluoride contamination of drinking water can disrupt male gametogenesis and steroidogenesis and induce testicular oxidative stress. Treatment of rats with sodium fluoride at the dose of 20 mg/kg/day for 28 days resulted in significant diminution of testicular Delta5,3beta-hydroxysteroid dehydrogenase (HSD) and 17beta-hydroxysteroid dehydrogenase (HSD) activities and low plasma levels of testosterone, follicular stimulating hormone (FSH) and leutinizing hormone (LH). Spermatogenesis inhibited after sodium fluoride treatment has been assessed here by the quantification of different generation of germ cells like spermatogonia A (ASg), preleptotene spermatocyte (PLSc), midpachytene spermatocyte (MPSc) and step 7 spermatid (7Sd) at stage VII of seminiferous epithelial cycle. Furthermore, fluoride treatment was associated with low activities of testicular, prostatic and epididymal catalase (CAT), superoxide dismutase (SOD) and peroxidase along with elevation of malondialdehyde (MDA) and conjugated dienes (CD) in those tissues. Co-administration of calcium and Vitamin-E with fluoride resulted in a significant recovery from testicular disorders and oxidative stress in the testis and male accessory sex organs. The results of this study demonstrate that fluoride exposure, at the dose available in drinking water in contaminated areas, led to inhibition of testicular gametogenesis and steroidogenesis in association with oxidative stress in the testis and male accessory sex organs, which are protected significantly by dietary agents like Vitamin-E and calcium.
- Subjects :
- 17-Hydroxysteroid Dehydrogenases metabolism
3-Hydroxysteroid Dehydrogenases metabolism
Animals
Calcium Chloride administration & dosage
Calcium Chloride blood
Catalase metabolism
Drug Therapy, Combination
Enzyme Reactivators pharmacology
Follicle Stimulating Hormone blood
Genitalia, Male drug effects
Genitalia, Male enzymology
Genitalia, Male pathology
Intubation, Intratracheal
Luteinizing Hormone blood
Male
Malondialdehyde metabolism
Organ Size drug effects
Rats
Sodium Fluoride administration & dosage
Sodium Fluoride blood
Spermatocytes drug effects
Spermatogenesis drug effects
Spermatogonia drug effects
Superoxide Dismutase metabolism
Testicular Diseases chemically induced
Testicular Diseases pathology
Testosterone blood
Vitamin E administration & dosage
Vitamin E blood
Vitamins administration & dosage
Vitamins blood
Vitamins therapeutic use
Calcium Chloride therapeutic use
Sodium Fluoride toxicity
Testicular Diseases drug therapy
Vitamin E therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0890-6238
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 16769200
- Full Text :
- https://doi.org/10.1016/j.reprotox.2006.05.001