Back to Search
Start Over
High grade superficial (G3t1) transitional cell carcinoma of the bladder treated with intravesical Bacillus Calmette-Guerin (BCG).
- Source :
-
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2003 Dec; Vol. 22 (4 Suppl), pp. 223-7. - Publication Year :
- 2003
-
Abstract
- Objectives: Immunotherapy with Bacillus Calmette Guerin (BCG) has been widely used recently as primary option for treatment of high grade superficial (G3T1) carcinoma of the bladder. We describe our long term experience of therapy of G3T1 bladder cancer.<br />Methods: From January 1982 to December 2000, 785 patients were diagnosed with superficial bladder cancer. All patients underwent preoperative CT scan and transurethral resection of the bladder. Eighty-six patients (11%) had histological high grade superficial bladder cancer infiltrating the lamina propria. This group was treated with the following schedule of BCG Pasteur strain plus maintenance. Four cycles BCG, 6 instillations per cycle, first cycle weekly x 6, second cycle every 2 weeks x 6, third cycle monthly x 6, fourth cycle (maintenance) every 3 months x 6 instillations.<br />Results: The median follow-up is 91 months (30-197 months). The overall recurrence rate was 35% (30/86). The median time to recurrence was 29 months (5-128 months). Of these patients, 12 (14%) had progression at a median follow-up of 16 months (range 8-58 months). Cystectomy was needed in 8 (9%) patients. Death due to disease occurred in 5/86 (6%) patients. One patient died due to adenocarcinoma at the ureterosigmoidostomy site. Sixty-four (74%) patients are alive at a median follow-up of 71 months (range 28-197 months). Sixty patients (70%) are alive with an intact bladder.<br />Conclusions: Treatment with BCG is a feasible conservative therapy for patients with primary G3T1 transitional bladder cancer. Long term results of BCG treatment are excellent. Cystectomy shouldn't be considered first line treatment for high grade superficial carcinoma of the bladder.
- Subjects :
- Administration, Intravesical
Adult
Aged
Aged, 80 and over
Carcinoma, Transitional Cell mortality
Disease Progression
Female
Humans
Male
Middle Aged
Neoplasm Recurrence, Local epidemiology
Survival Rate
Treatment Outcome
Urinary Bladder Neoplasms mortality
Carcinoma, Transitional Cell therapy
Immunotherapy
Mycobacterium bovis immunology
Urinary Bladder Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0392-9078
- Volume :
- 22
- Issue :
- 4 Suppl
- Database :
- MEDLINE
- Journal :
- Journal of experimental & clinical cancer research : CR
- Publication Type :
- Academic Journal
- Accession number :
- 16767936