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Intra-arterial chemiotherapy for invasive bladder cancer.
- Source :
-
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2003 Dec; Vol. 22 (4 Suppl), pp. 21-3. - Publication Year :
- 2003
-
Abstract
- Standard treatment for transitional cell carcinoma confined to the bladder is radical cystectomy that allow to obtain an overall 5-year disease-free survival rate only of 50-70%. It has been demonstrated that intra-arterial chemotherapy produces the same survival outcomes as radical cystectomy. This study aimed to evaluate the activity and toxicity of a bladder-sparing loco-regional treatment. Five patients with transitional cell carcinoma of the bladder (4 locally advanced and 1 pelvic relapse) were treated with doxorubycin 25 mg/m2, cisplatin 40 mg/m2 and methotrexate 50 mg/m2, all infused bolus via internal iliac arteries on day 1, every three weeks. We obtained 3 complete responses, 1 stable disease and 1 progression of disease. The treatment was well tolerated with a minimal hematological toxicity and no others major toxicity. Median disease free survival was 8 months (1-17), median overall survival was 22 months (2-55). This loco-regional regimen of chemotherapy is active and safe in locally advanced bladder cancer patients and permits a prolonged good quality of life regarding the maintenance of the physiological functions of the lower urinary tract.
- Subjects :
- Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols adverse effects
Carcinoma, Transitional Cell mortality
Cisplatin administration & dosage
Cisplatin adverse effects
Disease-Free Survival
Doxorubicin administration & dosage
Doxorubicin adverse effects
Humans
Infusions, Intra-Arterial
Male
Methotrexate administration & dosage
Methotrexate adverse effects
Middle Aged
Quality of Life
Urinary Bladder Neoplasms mortality
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Carcinoma, Transitional Cell drug therapy
Urinary Bladder Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0392-9078
- Volume :
- 22
- Issue :
- 4 Suppl
- Database :
- MEDLINE
- Journal :
- Journal of experimental & clinical cancer research : CR
- Publication Type :
- Academic Journal
- Accession number :
- 16767901