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Oxygen sensors in hypoxic pulmonary vasoconstriction.
- Source :
-
Cardiovascular research [Cardiovasc Res] 2006 Sep 01; Vol. 71 (4), pp. 620-9. - Publication Year :
- 2006
-
Abstract
- Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus causes acute pulmonary hypertension. Despite intensive research, the underlying mechanisms of HPV have not been fully elucidated. Deciphering signalling pathways that result in HPV could suggest novel approaches to address a failure of HPV, as well as for the treatment of pulmonary hypertension associated with HPV. Within this context, this review focuses on current concepts in the oxygen sensing mechanisms that underlie HPV.
- Subjects :
- Adenosine Triphosphate metabolism
Animals
Calcium metabolism
Cytochrome P-450 Enzyme System metabolism
Heme Oxygenase (Decyclizing) metabolism
Humans
Hypertension, Pulmonary metabolism
Mitochondria metabolism
Reactive Oxygen Species metabolism
Vasoconstriction physiology
Hypoxia metabolism
Lung metabolism
Oxygen metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0008-6363
- Volume :
- 71
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cardiovascular research
- Publication Type :
- Academic Journal
- Accession number :
- 16765922
- Full Text :
- https://doi.org/10.1016/j.cardiores.2006.04.009