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Improved protection of mice against lethal respiratory infection with Coccidioides posadasii using two recombinant antigens expressed as a single protein.
- Source :
-
Vaccine [Vaccine] 2006 Jul 26; Vol. 24 (31-32), pp. 5904-11. Date of Electronic Publication: 2006 Apr 18. - Publication Year :
- 2006
-
Abstract
- Two recombinant antigens which individually protect mice from lethal intranasal infection were studied in combination, either as a mixture of two separately expressed proteins or as a single chimeric expression product. Mice vaccinated with either combination survived longer than mice given single antigens. Immunized mice also exhibited specific IgG immunoglobulins and yielded splenocytes which produced interferon-gamma in response to either antigen. The chimeric antigen has the practical advantage of offering enhanced protection from multiple components without increasing production costs.
- Subjects :
- Amino Acid Sequence
Animals
Coccidioidomycosis microbiology
Female
Fungal Proteins genetics
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Respiratory Tract Infections microbiology
Vaccines, Synthetic therapeutic use
Coccidioides
Coccidioidomycosis prevention & control
Fungal Proteins therapeutic use
Fungal Vaccines therapeutic use
Respiratory Tract Infections prevention & control
Vaccines, Subunit therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0264-410X
- Volume :
- 24
- Issue :
- 31-32
- Database :
- MEDLINE
- Journal :
- Vaccine
- Publication Type :
- Academic Journal
- Accession number :
- 16759762
- Full Text :
- https://doi.org/10.1016/j.vaccine.2006.04.002