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[Evaluation of some functions of polymorphonuclear granulocytes in lung cancer patients during chemotherapy].
- Source :
-
Pneumonologia i alergologia polska [Pneumonol Alergol Pol] 2005; Vol. 73 (2), pp. 167-71. - Publication Year :
- 2005
-
Abstract
- Lung cancer (NSCLC and SCLC) is one of most frequent carcinoma. Lung cancer is at the top of the list of cancers causing mortality in males. Many patients are qualified to chemotherapy which causes neutropenia. The aim of this work was to evaluate the number and function of (phagocytosis, test of NBT reduction and MPO activity) of leukocytes in patients with lung cancer before chemotherapy, during leukopenia and after stimulation with granulocyte colony stimulating factor (G-CSF). Patients with lung cancer have increased number of leukocytes before the treatment. After chemotherapy the number of leukocytes decreases. Treatment with G-CSF increases the number of leukocytes but it doesn't increase their ability to phagocytosis and to NBT reduction.
- Subjects :
- Adult
Antineoplastic Combined Chemotherapy Protocols adverse effects
Antineoplastic Combined Chemotherapy Protocols pharmacology
Carcinoma, Non-Small-Cell Lung immunology
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Small Cell immunology
Carcinoma, Small Cell pathology
Cisplatin administration & dosage
Granulocyte Colony-Stimulating Factor administration & dosage
Granulocytes cytology
Granulocytes drug effects
Humans
Leukocyte Count
Lung Neoplasms immunology
Lung Neoplasms pathology
Male
Neutropenia chemically induced
Neutropenia prevention & control
Phagocytosis drug effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Carcinoma, Small Cell drug therapy
Granulocytes immunology
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- Polish
- ISSN :
- 0867-7077
- Volume :
- 73
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pneumonologia i alergologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 16756147