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Pregnancy in patients with beta-thalassemia intermedia: outcome of mothers and newborns.
- Source :
-
American journal of hematology [Am J Hematol] 2006 Jul; Vol. 81 (7), pp. 499-502. - Publication Year :
- 2006
-
Abstract
- Little is known about the outcome of pregnancy in women with beta-thalassemia intermedia (TI). Over 10 years, maternal and neonatal outcomes of women with TI followed at a single thalassemia center were reviewed. Nine spontaneous pregnancies in five women with TI were studied. Six pregnancies resulted in live newborns; two were complicated by first-trimester abortions and one by an unexplained intrauterine fetal death at 36 weeks' gestation. Two patients had splenectomy before pregnancy: one required cesarean delivery and splenectomy at 31(2/7) weeks' gestation for worsening hemolytic anemia and thrombocytopenia and another had splenectomy 8 weeks postpartum for symptomatic hypersplenism. Two patients had received transfusions before pregnancy, and two required them for the first time during pregnancy and developed antibodies, which contributed to worsening of their anemia and repeated transfusions. The mean number of transfusions received during pregnancy was 8.0 +/- 5.2 units. The mean lowest hemoglobin level in pregnancy was 5.2 +/- 2.0 g/dl. Cesarean delivery was performed in 42.9% of cases. Mean gestational age at delivery was 36.7+/- 3.1 weeks with intrauterine growth restriction (IUGR) complicating 57.1% of cases. In conclusion, IUGR complicates more than half of pregnancies with TI. Transfusions are needed in most cases, even in non-transfusion-dependent patients. Postpartum splenectomy might be necessary in some patients.
- Subjects :
- Abortion, Spontaneous blood
Anemia, Hemolytic blood
Anemia, Hemolytic etiology
Anemia, Hemolytic therapy
Autoantibodies blood
Blood Transfusion
Cesarean Section
Female
Fetal Death blood
Fetal Growth Retardation blood
Gestational Age
Humans
Pregnancy
Splenectomy
Thrombocytopenia blood
Thrombocytopenia etiology
Thrombocytopenia therapy
Pregnancy Complications, Hematologic blood
Pregnancy Complications, Hematologic therapy
Pregnancy Outcome
beta-Thalassemia blood
beta-Thalassemia complications
beta-Thalassemia therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0361-8609
- Volume :
- 81
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 16755576
- Full Text :
- https://doi.org/10.1002/ajh.20654