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DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase.
- Source :
-
Journal of bacteriology [J Bacteriol] 2006 Jun; Vol. 188 (12), pp. 4577-80. - Publication Year :
- 2006
-
Abstract
- The Cdc6 proteins from the archaeon Methanothermobacter thermautotrophicus were previously shown to bind double-stranded DNA. It is shown here that the proteins also bind single-stranded DNA. Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6.
Details
- Language :
- English
- ISSN :
- 0021-9193
- Volume :
- 188
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of bacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 16740965
- Full Text :
- https://doi.org/10.1128/JB.00168-06