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Psychoactive drugs and regulation of the cAMP/PKA/DARPP-32 cascade in striatal medium spiny neurons.
- Source :
-
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2007; Vol. 31 (1), pp. 79-88. Date of Electronic Publication: 2006 May 30. - Publication Year :
- 2007
-
Abstract
- Changes in activity of the medium spiny neurons (MSNs) of dorsal and ventral striatum result in alterations of motor performance, ranging from rapid increases or decreases in locomotor activity, to long-term modifications of motor behaviours. In the dorsal striatum, MSNs can be distinguished based on the organization of their connectivity to substantia nigra pars reticulata (SNpr) and internal segment of the globus pallidus (GPi), which, in turn, control thalamocortical neurons. Approximately half of the MSNs project directly to SNpr and GPi, their activation leading to disinhibition of thalamocortical neurons and increased motor activity. The other subpopulation of MSNs connects to SNpr and GPi indirectly and when activated promotes inhibition of thalamocortical neurons, thereby reducing motor activity. The dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) is a modulator of the cAMP signalling pathway, highly expressed in MSNs. This review discusses the regulation of DARPP-32 exerted by psychoactive substances in specific populations of striatal projection neurons and its involvement in short- and long-term motor responses.
- Subjects :
- Amphetamine pharmacology
Animals
Caffeine pharmacology
Cannabinoids pharmacology
Cocaine pharmacology
Cyclic AMP metabolism
Cyclic AMP-Dependent Protein Kinases metabolism
Dopamine and cAMP-Regulated Phosphoprotein 32 metabolism
Neostriatum cytology
Neostriatum metabolism
Neural Pathways drug effects
Neural Pathways metabolism
Neurons cytology
Neurons metabolism
Psychomotor Performance drug effects
Psychomotor Performance physiology
Second Messenger Systems physiology
Signal Transduction physiology
Neostriatum drug effects
Neurons drug effects
Psychotropic Drugs pharmacology
Second Messenger Systems drug effects
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0149-7634
- Volume :
- 31
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Neuroscience and biobehavioral reviews
- Publication Type :
- Academic Journal
- Accession number :
- 16730373
- Full Text :
- https://doi.org/10.1016/j.neubiorev.2006.03.003