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Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats.

Authors :
Sasamoto T
Sano N
Takikawa H
Source :
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2006 Jan; Vol. 21 (1 Pt 1), pp. 26-31.
Publication Year :
2006

Abstract

Background and Aims: There are several reports on the biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rat liver, but the results are controversial. In order to dissolve the discrepancy between previous works about the role of hepatic zonation on the hepatic handling of the substrates of multidrug resistance protein 2, the biliary excretion of sulfated bile acids, pravastatin and phenolphthalein glucuronide was studied in zone 1- and zone 3-injured rats.<br />Methods: Zone 1 and zone 3 injury were caused by allyl alcohol and bromobenzene, respectively. Bile acid sulfates, pravastatin and phenolphthalein glucuronide were administered i.v. to bile duct-cannulated rats, and their biliary excretion was studied.<br />Results: The biliary excretion of a tracer dose of taurolithocholate-3-sulfate and its excretory maximum were unchanged in zone 1 injury, but were diminished in zone 3 injury, whereas the biliary excretion of taurochenodeoxycholate-3-sulfate was unchanged in zone 1 and zone 3 injury. The biliary excretion of pravastatin and phenolphthalein glucuronide was markedly decreased only in zone 3 injury, whereas the excretory maximum of phenolphthalein glucuronide was decreased in both zone 1 and zone 3 injury.<br />Conclusions: These findings indicate that zone 3 is important for the biliary excretion of substrates of multidrug resistance protein 2.

Details

Language :
English
ISSN :
0815-9319
Volume :
21
Issue :
1 Pt 1
Database :
MEDLINE
Journal :
Journal of gastroenterology and hepatology
Publication Type :
Academic Journal
Accession number :
16706808
Full Text :
https://doi.org/10.1111/j.1440-1746.2005.04212.x