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Biliary excretion of sulfated bile acids and organic anions in zone 1- and zone 3-injured rats.
- Source :
-
Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2006 Jan; Vol. 21 (1 Pt 1), pp. 26-31. - Publication Year :
- 2006
-
Abstract
- Background and Aims: There are several reports on the biliary excretion of bile acids and organic anions in zone 1- and zone 3-injured rat liver, but the results are controversial. In order to dissolve the discrepancy between previous works about the role of hepatic zonation on the hepatic handling of the substrates of multidrug resistance protein 2, the biliary excretion of sulfated bile acids, pravastatin and phenolphthalein glucuronide was studied in zone 1- and zone 3-injured rats.<br />Methods: Zone 1 and zone 3 injury were caused by allyl alcohol and bromobenzene, respectively. Bile acid sulfates, pravastatin and phenolphthalein glucuronide were administered i.v. to bile duct-cannulated rats, and their biliary excretion was studied.<br />Results: The biliary excretion of a tracer dose of taurolithocholate-3-sulfate and its excretory maximum were unchanged in zone 1 injury, but were diminished in zone 3 injury, whereas the biliary excretion of taurochenodeoxycholate-3-sulfate was unchanged in zone 1 and zone 3 injury. The biliary excretion of pravastatin and phenolphthalein glucuronide was markedly decreased only in zone 3 injury, whereas the excretory maximum of phenolphthalein glucuronide was decreased in both zone 1 and zone 3 injury.<br />Conclusions: These findings indicate that zone 3 is important for the biliary excretion of substrates of multidrug resistance protein 2.
- Subjects :
- ATP-Binding Cassette Transporters metabolism
Animals
Biological Transport
Bromobenzenes
Chemical and Drug Induced Liver Injury
Liver pathology
Liver Diseases pathology
Male
Phenolphthaleins pharmacokinetics
Pravastatin pharmacokinetics
Propanols
Rats
Rats, Sprague-Dawley
Taurolithocholic Acid analogs & derivatives
Taurolithocholic Acid pharmacokinetics
Anions
Bile metabolism
Bile Acids and Salts pharmacokinetics
Biliary Tract metabolism
Liver metabolism
Liver Diseases metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0815-9319
- Volume :
- 21
- Issue :
- 1 Pt 1
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology and hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 16706808
- Full Text :
- https://doi.org/10.1111/j.1440-1746.2005.04212.x