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Evaluation of the abuse potential of pagoclone, a partial GABAA agonist.
- Source :
-
Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2006 Jun; Vol. 26 (3), pp. 268-73. - Publication Year :
- 2006
-
Abstract
- This study assessed the abuse potential of pagoclone, a partial agonist at the gamma-aminobutyric acid type A (GABAA) benzodiazepine receptor site, in healthy recreational drug users. Twenty-three young adults, who reported past recreational use of sedative drugs or alcohol, participated in 4 sessions during which capsules containing pagoclone (doses: 1.2 mg, the higher end of the proposed therapeutic dose range, and 4.8 mg, a 4-fold higher dose), diazepam (dose, 30 mg), or placebo were randomly administered under double-blind conditions. Subjective ratings of mood, drug effects, and psychomotor tests were completed at regular intervals after ingesting the capsules. On most of the standardized measures of abuse potential, pagoclone (dose, 4.8 mg) was rated as being similar to diazepam. Both drugs increased the ratings of good effects and drug liking. However, pagoclone also produced some adverse mood effects that might limit its potential to be used recreationally, and it produced fewer sedativelike effects on some measures. In general, the results with these doses indicate that the abuse potential of pagoclone is similar to that of diazepam, although its profile as a partial agonist suggests that differences between the drugs may emerge at higher doses.
- Subjects :
- Adolescent
Adult
Affect drug effects
Blood Pressure physiology
Diazepam pharmacology
Double-Blind Method
Euphoria drug effects
Female
Heart Rate physiology
Humans
Hypnotics and Sedatives pharmacology
Isoindoles
Male
Middle Aged
Psychomotor Performance drug effects
Surveys and Questionnaires
Verbal Learning drug effects
GABA Agonists adverse effects
GABA-A Receptor Agonists
Naphthyridines adverse effects
Substance-Related Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 0271-0749
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of clinical psychopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 16702891
- Full Text :
- https://doi.org/10.1097/01.jcp.0000218983.61683.96