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Colorectal cancer: genetics of development and metastasis.
- Source :
-
Journal of gastroenterology [J Gastroenterol] 2006 Mar; Vol. 41 (3), pp. 185-92. - Publication Year :
- 2006
-
Abstract
- It has been well documented that there are two major pathways in colorectal carcinogenesis. One is the chromosomal instability pathway (adenoma-carcinoma sequence), which is characterized by allelic losses on chromosome 5q (APC), 17p (p53), and 18q (DCC/SMAD4), and the other is a pathway that involves microsatellite instability. Recent progress in molecular biology, however, has shown that colorectal carcinogenesis is not necessarily clearly divided into these two pathways, but is in fact more complicated. Other routes, including the transforming growth factor-beta/SMAD pathway, the serrated pathway, and the epigenetic pathway, have been reported. Cross talk among these pathways has also been reported. In the invasion and metastasis steps of colorectal cancers, many more genes have now been identified as being involved in proteolysis, adhesion, angiogenesis, and cell growth. Recently accumulated evidence indicates that colorectal cancer is a genetically heterogeneous and complicated disease.
- Subjects :
- Chromosomal Instability
Colorectal Neoplasms pathology
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic
Genes, Tumor Suppressor
Genes, ras
Genetic Predisposition to Disease
Humans
Microsatellite Instability
Signal Transduction genetics
Smad4 Protein genetics
Transforming Growth Factor beta genetics
Tumor Suppressor Proteins genetics
Adenocarcinoma genetics
Carcinoma genetics
Cell Transformation, Neoplastic genetics
Colorectal Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0944-1174
- Volume :
- 41
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 16699851
- Full Text :
- https://doi.org/10.1007/s00535-006-1801-6