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Role of aldosterone blockade for treatment of heart failure and post-acute myocardial infarction.
- Source :
-
The American journal of cardiology [Am J Cardiol] 2006 May 22; Vol. 97 (10A), pp. 34F-40F. Date of Electronic Publication: 2006 Apr 07. - Publication Year :
- 2006
-
Abstract
- Heart failure continues to significantly impact morbidity and mortality after acute myocardial infarction (AMI), especially when associated with left ventricular systolic dysfunction (LVSD). Therefore, routine use of optimal therapy for patients with heart failure after AMI is needed in the future. Data from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) has demonstrated that addition of eplerenone to standard therapy in patients with LVSD and clinical heart failure post-AMI significantly improves outcomes in these patients, providing the basis for acceptance of aldosterone blockade as an integral component of therapy. However, further studies are needed to more broadly explore the usefulness of aldosterone blockade in heart failure therapy. As research clarifies the many complex pathophysiologic processes involved in post-AMI remodeling, treatment should continue to move beyond symptom-targeted therapies to disease- and mechanism-targeted therapies that will further improve outcomes in the setting of heart failure post-AMI and beyond.
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 97
- Issue :
- 10A
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 16698333
- Full Text :
- https://doi.org/10.1016/j.amjcard.2006.03.009