Back to Search
Start Over
The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms.
- Source :
-
Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 2005 Dec; Vol. 37 (6), pp. 509-15. - Publication Year :
- 2005
-
Abstract
- The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.
Details
- Language :
- English
- ISSN :
- 0145-479X
- Volume :
- 37
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of bioenergetics and biomembranes
- Publication Type :
- Academic Journal
- Accession number :
- 16691491
- Full Text :
- https://doi.org/10.1007/s10863-005-9500-1