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Molecular aspects of disease pathogenesis in the transmissible spongiform encephalopathies.
- Source :
-
Molecular biotechnology [Mol Biotechnol] 2006 May; Vol. 33 (1), pp. 71-88. - Publication Year :
- 2006
-
Abstract
- The transmissible spongiform encephalopathies (TSE), or prion diseases, are a group of rare, fatal, and transmissible neurodegenerative diseases of mammals for which there are no known viral or bacterial etiological agents. The bovine form of these diseases, bovine spongiform encephalopathy (BSE), has crossed over into humans to cause variant Creutzfeldt-Jakob disease. As a result, BSE and the TSE diseases are now considered a significant threat to human health. Understanding the basic mechanisms of TSE pathogenesis is essential for the development of effective TSE diagnostic tests and anti-TSE therapeutic regimens. This review provides an overview of the molecular mechanisms that underlie this enigmatic group of diseases.
Details
- Language :
- English
- ISSN :
- 1073-6085
- Volume :
- 33
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Molecular biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 16691009
- Full Text :
- https://doi.org/10.1385/MB:33:1:71