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BACE-1 inhibition by a series of psi[CH2NH] reduced amide isosteres.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jul 15; Vol. 16 (14), pp. 3635-8. Date of Electronic Publication: 2006 May 11. - Publication Year :
- 2006
-
Abstract
- A series of beta-site amyloid precursor protein cleaving enzyme (BACE-1) inhibitors containing a psi(CH2NH) reduced amide bond were synthesized. Incorporation of this reduced amide isostere as a non-cleavable peptide surrogate afforded inhibitors possessing low nanomolar potencies in both an enzymatic and cell-based assay.
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16690314
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.04.076