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[Effects of Yiqi Jiangzhuo Decoction on transforming growth factor-beta1 mRNA expression in treating ventricular remodeling in mice with repetitive CVB3m infection caused viral myocarditis].
- Source :
-
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine [Zhongguo Zhong Xi Yi Jie He Za Zhi] 2006 Apr; Vol. 26 (4), pp. 341-3. - Publication Year :
- 2006
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Abstract
- Objective: To investigate the effects of Yiqi Jiangzhuo Decoction (YJD) on transforming growth factor-beta1(TGF-beta1) mRNA expression in treating ventricular remodeling in viral myocarditis.<br />Methods: After being established into chronic viral myocarditis model by 4 times repetitively infecting with gradient multiplicative CVB3m, 160 male mice were divided into the blank group, the model group, the TCM treated group and the Western medicine treated group. On the 10th, 30th and 60th day after the last time of infection, mice were killed to observe their pathological changes of myocardium with HE staining and to detect TGF-beta1 mRNA expression in myocardial tissue with semi-quantitative RT-PCR method.<br />Results: Pathological changes of myocardium alleviated, and TGF-beta1 mRNA expression distribution area reduced significantly in the two treated groups, as compared with those in the model group (all P < 0.05).<br />Conclusion: YJD could inhibit the hyperplasia and reconstruction of ECM by down-regulating TGF-beta1 mRNA expression to improve cardiac pathological changes in myocarditis, so as to prevent the occurrence of ventricular remodeling and the conversion of disease to dilative cardiomyopathy.
- Subjects :
- Animals
Enterovirus B, Human drug effects
Gene Expression drug effects
Male
Mice
Myocarditis pathology
Myocarditis virology
Phytotherapy
RNA, Messenger biosynthesis
RNA, Messenger genetics
Recurrence
Reverse Transcriptase Polymerase Chain Reaction
Ventricular Remodeling genetics
Ventricular Remodeling physiology
Coxsackievirus Infections drug therapy
Drugs, Chinese Herbal therapeutic use
Myocarditis drug therapy
Transforming Growth Factor beta1 genetics
Ventricular Remodeling drug effects
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1003-5370
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
- Publication Type :
- Academic Journal
- Accession number :
- 16689004