Two t(9;22) leukemia cell lines (NALM-24 and NALM-25) with bi-phenotypic characteristics and an EBV-positive B-cell non-leukemia cell line (B262) established from a patient with acute lymphoblastic leukemia.

Authors :: Matsuo Y
Ariyasu T
Adachi T
Tsubota T
Minowada J
Source :: Human cell [Hum Cell] 1991 Dec; Vol. 4 (4), pp. 339-42.
Publication Year :: 1991
Abstract: Based on the immunophenotypic, cytogenetic and genotypic findings, two unique leukemia cell lines, NALM-24 and NALM-25, and an EBV-transformed "normal" B-lymphoblastoid cell line (B262) from a patient with ALL were established and characterized. NALM-24 and NALM-25 are unique in that expression of both show B cell and myeloid cell features with the t(9;22) chromosome in single clonal leukemic cell populations.

Subjects :: Adult
Antigens, Surface analysis
B-Lymphocytes pathology
Blotting, Southern
Cell Line, Transformed
Cell Transformation, Viral
DNA, Neoplasm analysis
Female
Herpesvirus 4, Human
Humans
Karyotyping
Philadelphia Chromosome
Precursor Cell Lymphoblastic Leukemia-Lymphoma genetics
Tumor Cells, Cultured
Precursor Cell Lymphoblastic Leukemia-Lymphoma pathology

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