Back to Search
Start Over
The mutagenic potential of madder root in dyeing processes in the textile industry.
- Source :
-
Mutation research [Mutat Res] 2006 Jun 16; Vol. 605 (1-2), pp. 22-9. Date of Electronic Publication: 2006 May 04. - Publication Year :
- 2006
-
Abstract
- The roots of Rubia tinctorum L. have a long tradition of being used in dyeing processes of textiles from centuries ago until the present time. The colouring principles belong to the class of hydroxyanthraquinones. Concern arose because several of these compounds were recognised as mutagenic in vitro and even carcinogenic in rodents. To assess the possible risk to humans caused by coloured textiles, mutagenicity was investigated with two madder root samples of different origin (Iran and Bhutan) along the entire dyeing process from root extracts to the dyed wool. The Salmonella/microsome test (Ames assay) with the strains TA98, TA100 and TA1537 was used. Significant mutagenic effects could be detected in madder root extracts and also in the final product, the dyed wool. Madder root from Iran showed considerably higher mutagenic responses than samples from Bhutan. Analytical investigations of the extracts by HPLC showed the presence of a spectrum of anthraquinones typical for madder root. Three mutagenic compounds, lucidine, rubiadine and purpuroxanthine, together with the non-mutagenic alizarine could be detected. The mutagenic response of the different samples was positively correlated with the concentration of the mutagenic anthraquinones, and with lucidine in particular. Based on these investigations a risk to dye-house workers and users of textiles dyed with R. tinctorum must be anticipated.
- Subjects :
- Animals
Anthraquinones isolation & purification
Anthraquinones pharmacology
Anthraquinones toxicity
Chromatography, High Pressure Liquid
Coloring Agents isolation & purification
Heterocyclic Compounds, 4 or More Rings isolation & purification
Heterocyclic Compounds, 4 or More Rings toxicity
Humans
Mutagenicity Tests
Mutagens isolation & purification
Plant Extracts chemistry
Quinolines isolation & purification
Quinolines toxicity
Salmonella drug effects
Salmonella genetics
Salmonella growth & development
Wool
Xanthines isolation & purification
Xanthines toxicity
Coloring Agents toxicity
Mutagens toxicity
Plant Roots chemistry
Rubia chemistry
Textile Industry ethics
Subjects
Details
- Language :
- English
- ISSN :
- 1873-135X
- Volume :
- 605
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Mutation research
- Publication Type :
- Academic Journal
- Accession number :
- 16678474
- Full Text :
- https://doi.org/10.1016/j.mrgentox.2006.01.007