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Determination of estrogenic/antiestrogenic potential of antifertility substances using rat uterine peroxidase assay.
- Source :
-
Contraception [Contraception] 1991 Nov; Vol. 44 (5), pp. 549-57. - Publication Year :
- 1991
-
Abstract
- The effect of three compounds (clomiphene citrate, centchroman, embelin) and plant-derived methanolic extracts (Abutilon indicum and Butea monosperma) was studied on uterotropic and uterine peroxidase activities in ovariectomized rats. It was observed that these two parameters were highly correlated in response to treatment with these test materials and also to estradiol. It was suggested that the uterine peroxidase assay could be utilized as a biochemical parameter in the screening of new antifertility agents for their estrogenic/antiestrogenic properties.
- Subjects :
- Animals
Benzoquinones pharmacology
Centchroman pharmacology
Clomiphene pharmacology
Dose-Response Relationship, Drug
Drug Interactions
Female
Immunoenzyme Techniques
Organ Size drug effects
Peroxidase drug effects
Peroxidase metabolism
Plant Extracts pharmacology
Rats
Rats, Inbred Strains
Uterus anatomy & histology
Contraceptives, Oral pharmacology
Estradiol pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0010-7824
- Volume :
- 44
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Contraception
- Publication Type :
- Academic Journal
- Accession number :
- 1665776
- Full Text :
- https://doi.org/10.1016/0010-7824(91)90157-b