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Bioactive neolignans from Endlicheria dysodantha.
- Source :
-
Journal of natural products [J Nat Prod] 1991 Jul-Aug; Vol. 54 (4), pp. 1153-8. - Publication Year :
- 1991
-
Abstract
- From bioactivity-directed fractionation of the EtOH extract of Endlicheria dysodantha, dysodanthin A and dysodanthin B, which are new hexahydrobenzofuranoid neolignans, have been isolated. In addition, the known neolignans, compound 4, which is a burchellin analogue, and megaphone acetate [1] were isolated. All four neolignans showed activities in the brine shrimp lethality test; compounds 1-3 also inhibited the growth of crown gall tumors on potato discs and were cytotoxic to human tumor cells in culture. This is the first report of these neolignans isolated from the genus Endlicheria and of their completely assigned 1H-and 13C-nmr data.
- Subjects :
- Animals
Artemia drug effects
Drug Screening Assays, Antitumor
Humans
Lignans
Lignin isolation & purification
Magnetic Resonance Spectroscopy
Molecular Structure
Plants drug effects
Tumor Cells, Cultured drug effects
Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic isolation & purification
Lignin pharmacology
Plants analysis
Subjects
Details
- Language :
- English
- ISSN :
- 0163-3864
- Volume :
- 54
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 1665173
- Full Text :
- https://doi.org/10.1021/np50076a045