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Mice chronically fed a westernized experimental diet as a model of obesity, metabolic syndrome and osteoporosis.
- Source :
-
European journal of nutrition [Eur J Nutr] 2006 Aug; Vol. 45 (5), pp. 298-306. Date of Electronic Publication: 2006 Apr 28. - Publication Year :
- 2006
-
Abstract
- Background: Most studies in animals use diets with several features (for example low-fat, rich in micronutriments), likely to be strongly protective against chronic diseases.<br />Aim of the Study: The present study, performed in wild type outbred mice, was designed to evaluate the validity of a model of 'westernized' (W) diet reproducing, as closely as possible, the overall composition of an average human regime in western countries<br />Results: In contrast to the standard (S) diet, the W diet triggered a marked increase in adiposity with some characteristics of metabolic syndrome (hypercholesterolemia, hyperinsulinemia...). There was an heterogeneity in the propensity to become obese upon exposure to the W diet in female mice. Overweight mice also presented some disturbances of renal function, such as hyperalbuminuria and hypocitraturia. Mice adapted to the W diet showed a reduction of bone mineral density, especially the non-obese ones.<br />Conclusion: These data suggest that a model of westernized diet could be appropriate for exploring the effects of mutations, drugs, or specific nutritional factors in animals and could be more relevant for human situations.
- Subjects :
- Animals
Female
Humans
Metabolic Syndrome etiology
Metabolic Syndrome metabolism
Mice
Obesity etiology
Obesity metabolism
Osteoporosis etiology
Osteoporosis metabolism
Random Allocation
Urinalysis
Weight Gain
Diet adverse effects
Disease Models, Animal
Metabolic Syndrome epidemiology
Obesity epidemiology
Osteoporosis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1436-6207
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 16649091
- Full Text :
- https://doi.org/10.1007/s00394-006-0599-6