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Early prediction of poor outcome in extremely low birth weight infants by classification tree analysis.
Early prediction of poor outcome in extremely low birth weight infants by classification tree analysis.
- Source :
-
The Journal of pediatrics [J Pediatr] 2006 Apr; Vol. 148 (4), pp. 438-444. - Publication Year :
- 2006
-
Abstract
- Objective: To predict death or neurodevelopmental impairment (NDI) in extremely low birth weight infants by classification trees with recursive partitioning and automatic selection of optimal cut points of variables.<br />Study Design: Data from the Trial of Indomethacin Prophylaxis in Preterms were randomly divided into development (n=784) and validation sets (n=262). Three models were developed for the combined outcome of death (8 days to 18 months) or NDI (cerebral palsy, cognitive delay, deafness, or blindness at 18 months corrected age): antenatal: antenatal data; early neonatal: antenatal+first 3 days data; and first week: antenatal, first 3 days, and 4th to 8th days data. Decision trees were tested on the validation set.<br />Results: Variables associated with death/NDI in each model were: Antenatal: Gestation<or=25.5 weeks and antenatal steroids<7 days. Early neonatal: Birth weight<or=787 g and fluid intake>01 mL/kg/d. First week: Birth weight<or=787 g: transfusion>3 mL/kg/d. Birth weight>787 g: cranial echodense intraparenchymal lesion and transfusion>1 mL/kg/d. Correct classification rates were 61% to 62% for all models.<br />Conclusions: The ability to predict long-term morbidity/death in extremely low birth weight infants does not improve significantly over the first week of life. Effects of different variables depend on age.
- Subjects :
- Developmental Disabilities epidemiology
Developmental Disabilities prevention & control
Female
Humans
Infant Mortality
Infant, Newborn
Infant, Premature, Diseases epidemiology
Infant, Premature, Diseases mortality
Infant, Premature, Diseases prevention & control
Male
Predictive Value of Tests
Prognosis
Sensitivity and Specificity
Decision Trees
Fetal Viability
Infant, Premature
Infant, Very Low Birth Weight
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3476
- Volume :
- 148
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 16647401
- Full Text :
- https://doi.org/10.1016/j.jpeds.2005.11.042