Nebulized amphotericin B combined with intravenous amphotericin B in rats with severe invasive pulmonary aspergillosis.

Authors :: Ruijgrok EJ
Fens MH
Bakker-Woudenberg IA
van Etten EW
Vulto AG
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2006 May; Vol. 50 (5), pp. 1852-4.
Publication Year :: 2006
Abstract: Nebulized amphotericin B (AMB) combined with intravenous AMB was studied in persistently leukopenic rats with invasive pulmonary aspergillosis. Pulmonary concentrations of AMB after aerosol treatment were substantially higher than after intravenous liposomal AMB. Nebulized liposomal AMB in addition to intravenous AMB resulted in significantly prolonged survival compared to controls.

Subjects :: Amphotericin B pharmacology
Animals
Antifungal Agents pharmacology
Biomarkers metabolism
Injections, Intravenous
Liposomes
Lung Diseases, Fungal microbiology
Nebulizers and Vaporizers microbiology
Rats
Severity of Illness Index
Treatment Outcome
Amphotericin B administration & dosage
Antifungal Agents administration & dosage
Aspergillosis drug therapy
Aspergillus fumigatus drug effects
Lung Diseases, Fungal drug therapy

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