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Effects of disorganization on choice reaction time and visual orientation in untreated schizophrenics.
- Source :
-
Dialogues in clinical neuroscience [Dialogues Clin Neurosci] 2006; Vol. 8 (1), pp. 53-8. - Publication Year :
- 2006
-
Abstract
- Several preattentive mechanisms have proved to be sensitive markers of clinical change in schizophrenia. Two related studies of visuospatial orientation used cued target detection combined with choice reaction time, short/long preparation, with or without a signal/target interval ("gap"/ "no-gap," to detect attentional disengagement difficulty in schizophrenia). End points were reaction times, alertness scores, attentional cost/benefit, and validity scores. Study 1, in 13 schizophrenics receiving second-generation antipsychotics and 13 controls, found the same impairment of disengagement as with neuroleptics, but intact reaction times and processing speed, with no hemispheric asymmetry. Study 2, in 12 untreated acute schizophrenics and 12 controls, showed slower reaction times, near-zero alertness in the fixation release condition, and impaired valid/invalid discrimination versus Syndrome Scale disorganization subscore (r = -0.81; P < 0.01). Early deficits in the preattentive orientation and visual. Early deficits in the preattentive orientation and visual detection phases are useful for assessing response to psychotropic treatment and establishing clinical correlates in acute schizophrenia.
- Subjects :
- Adult
Antipsychotic Agents therapeutic use
Attention Deficit Disorder with Hyperactivity drug therapy
Case-Control Studies
Choice Behavior drug effects
Cues
Female
Humans
Male
Neuropsychological Tests
Orientation drug effects
Photic Stimulation methods
Psychiatric Status Rating Scales
Reaction Time drug effects
Schizophrenia drug therapy
Statistics, Nonparametric
Attention Deficit Disorder with Hyperactivity etiology
Choice Behavior physiology
Orientation physiology
Reaction Time physiology
Schizophrenia complications
Schizophrenia physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1294-8322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Dialogues in clinical neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 16640114