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Seborrhoeic keratosis and malignancy: collision tumour or malignant transformation?
- Source :
-
The Australasian journal of dermatology [Australas J Dermatol] 2006 May; Vol. 47 (2), pp. 106-8. - Publication Year :
- 2006
-
Abstract
- A retrospective study of 813 histological specimens reported as seborrhoeic keratoses included 43 (5.3%) associated with non-melanoma skin cancer. Intraepidermal carcinoma (squamous cell carcinoma in situ) was the most common of these (36). There were five basal cell carcinomas (one with intraepidermal carcinoma also) and two invasive squamous cell carcinomas. No melanomas were reported. Twenty-seven of the intraepidermal carcinomas appeared to arise within the seborrhoeic keratosis as did one of the invasive squamous cell carcinomas. Of these 28 lesions, the head was the most common site. Fourteen were clinically diagnosed as a non-melanoma skin cancer with only nine clinically felt to be a seborrhoeic keratosis. These lesions may represent malignant transformation within the seborrhoeic keratosis. Twelve specimens reported adjacent dual pathologies, with the trunk and limbs the most common sites. Seven were diagnosed clinically as a skin malignancy, whereas three were thought to be solar keratoses. Clinically, the remaining two were seborrhoeic keratoses. The origin of the malignancy in these cases is less obvious and may represent collision tumours. Three curette specimens could not be assessed for architecture.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Basal Cell epidemiology
Carcinoma, Basal Cell etiology
Carcinoma, Basal Cell pathology
Carcinoma, Squamous Cell epidemiology
Carcinoma, Squamous Cell etiology
Carcinoma, Squamous Cell pathology
Cell Transformation, Neoplastic
Female
Head
Humans
Keratosis, Seborrheic etiology
Keratosis, Seborrheic pathology
Male
Medical Records
Middle Aged
Precancerous Conditions
Queensland epidemiology
Retrospective Studies
Skin Neoplasms epidemiology
Skin Neoplasms etiology
Skin Neoplasms pathology
Keratosis, Seborrheic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0004-8380
- Volume :
- 47
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Australasian journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 16637805
- Full Text :
- https://doi.org/10.1111/j.1440-0960.2006.00242.x