A potential novel strategy to separate therapeutic- and side-effects that are mediated via the same receptor: beta-arrestin2/G-protein coupling antagonists.

Authors :: Bruns IR
Chhum S
Dinh AT
Doerr H
Dunn NR
Ly YT
Mitman CL
Rickards HD
Sol C
Wan EW
Raffa RB
Source :: Journal of clinical pharmacy and therapeutics [J Clin Pharm Ther] 2006 Apr; Vol. 31 (2), pp. 119-28.
Publication Year :: 2006

Subjects :: Animals
Arrestins classification
Arrestins physiology
Humans
Receptors, G-Protein-Coupled classification
Receptors, G-Protein-Coupled physiology
beta-Arrestins
Analgesia
Analgesics, Opioid adverse effects
Analgesics, Opioid pharmacology
Arrestins antagonists & inhibitors
Morphine adverse effects
Morphine pharmacology
Receptors, G-Protein-Coupled antagonists & inhibitors

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