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Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jul 01; Vol. 16 (13), pp. 3430-3. Date of Electronic Publication: 2006 Apr 24. - Publication Year :
- 2006
-
Abstract
- The synthesis and preliminary structure-activity relationship of a series of pyrrolidinones are described. These pyrrolidinones have been characterized as novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) which are highly potent against wild-type and drug-resistant human immunodeficiency viruses (HIV-1).
- Subjects :
- Anti-HIV Agents chemistry
HIV Reverse Transcriptase antagonists & inhibitors
Humans
Microbial Sensitivity Tests
Molecular Structure
Pyrrolidinones chemistry
Reverse Transcriptase Inhibitors chemistry
Structure-Activity Relationship
Virus Replication drug effects
Anti-HIV Agents chemical synthesis
Anti-HIV Agents pharmacology
HIV-1 drug effects
Pyrrolidinones chemical synthesis
Pyrrolidinones pharmacology
Reverse Transcriptase Inhibitors chemical synthesis
Reverse Transcriptase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 16
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 16632349
- Full Text :
- https://doi.org/10.1016/j.bmcl.2006.04.012