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Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats.

Authors :
Saillenfait AM
Gallissot F
Sabaté JP
Bourges-Abella N
Cadot R
Morel G
Lambert AM
Source :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2006 Aug; Vol. 44 (8), pp. 1287-98. Date of Electronic Publication: 2006 Mar 06.
Publication Year :
2006

Abstract

Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6h/day, during days 6-20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000 ppm EB and 3000 ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000 ppm EB or 3000 ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.

Details

Language :
English
ISSN :
0278-6915
Volume :
44
Issue :
8
Database :
MEDLINE
Journal :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Type :
Academic Journal
Accession number :
16624470
Full Text :
https://doi.org/10.1016/j.fct.2006.02.006