Back to Search
Start Over
Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2006 Aug; Vol. 44 (8), pp. 1287-98. Date of Electronic Publication: 2006 Mar 06. - Publication Year :
- 2006
-
Abstract
- Pregnant Sprague-Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6h/day, during days 6-20 of gestation. Maternal toxicity, evidenced by decreased in body weight gain and food consumption, tended to be greater after simultaneous exposures to the high concentrations of 1000 ppm EB and 3000 ppm MEK, when compared to the treatments with individual compounds. No significant increase in embryo/fetal lethality or incidence of malformations and variations was observed in any of the treatment groups. Fetal body weight was significantly reduced after individual treatment with 1000 ppm EB or 3000 ppm MEK, and in the combined groups. There was no evidence of interaction between EB and MEK in causing developmental toxicity.
- Subjects :
- Animals
Body Weight drug effects
Body Weight physiology
Dose-Response Relationship, Drug
Eating drug effects
Eating physiology
Female
Fetal Resorption
Fetus
Histocytochemistry
Kidney drug effects
Litter Size drug effects
Litter Size physiology
Liver drug effects
Male
Mandelic Acids urine
Organ Size drug effects
Organ Size physiology
Pregnancy
Rats
Rats, Sprague-Dawley
Benzene Derivatives toxicity
Butanones toxicity
Fetal Development drug effects
Inhalation Exposure
Maternal Exposure
Subjects
Details
- Language :
- English
- ISSN :
- 0278-6915
- Volume :
- 44
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 16624470
- Full Text :
- https://doi.org/10.1016/j.fct.2006.02.006