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Association of plasminogen activators and matrix metalloproteinase-9 proteolytic cascade with blood-CNS barrier damage of angiostrongyliasis.
- Source :
-
International journal of experimental pathology [Int J Exp Pathol] 2006 Apr; Vol. 87 (2), pp. 113-9. - Publication Year :
- 2006
-
Abstract
- Blood-central nervous system (blood-CNS) barrier breakdown, an important pathophysiological event in meningitis, results in extravasation of leucocytes into subarachnoid space. The blood-CNS barrier disruption is mediated by primarily two enzyme systems, the plasminogen activators (PAs) and matrix metalloproteinases (MMPs). The present study showed that the activities of tissue-type PA (tPA), urokinase-type activator (uPA) and MMP-9 in cerebrospinal-like fluid (CSF-like fluid) were significantly increased in mice with eosinophilic meningitis compared with uninfected mice. Eosinophilia significantly correlated with tPA, uPA and MMP-9 activities, and albumin concentration. In addition, when GM6001, a specific matrix metalloproteinase blocker, was injected into infected mice, MMP-9 activity and total protein concentrations declined from their preinjection highs. These results suggest that the PAs and MMP-9 proteolytic cascade may be associated with blood-CNS barrier disruption in eosinophilic meningitis caused by Angiostrongylus cantonensis.
- Subjects :
- Albumins cerebrospinal fluid
Angiostrongylus cantonensis
Animals
Blood Proteins cerebrospinal fluid
Blood-Brain Barrier microbiology
Dipeptides pharmacology
Eosinophilia blood
Eosinophilia cerebrospinal fluid
Eosinophilia microbiology
Eosinophils
Leukocyte Count
Male
Meningitis blood
Meningitis microbiology
Mice
Mice, Inbred BALB C
Protease Inhibitors pharmacology
Strongylida Infections blood
Tissue Plasminogen Activator cerebrospinal fluid
Urokinase-Type Plasminogen Activator cerebrospinal fluid
Blood-Brain Barrier injuries
Matrix Metalloproteinase 9 cerebrospinal fluid
Meningitis cerebrospinal fluid
Plasminogen Activators cerebrospinal fluid
Strongylida Infections cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 0959-9673
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 16623755
- Full Text :
- https://doi.org/10.1111/j.0959-9673.2006.00459.x